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- A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity
A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity
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A deep learning-based model DeepSpCas9 to predict SpCas9 activity
Blackjack mutations improve the on-target activities of increased fidelity variants of SpCas9 with 5′G-extended sgRNAs
A kinetic model improves off-target predictions and reveals the physical basis of SpCas9 fidelity
A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity
PDF) A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity
Improving the on-target activity of high-fidelity Cas9 editors by combining rational design and random mutagenesis
Strategies to overcome the main challenges of the use of CRISPR/Cas9 as a replacement for cancer therapy, Molecular Cancer
Interpretable neural architecture search and transfer learning for understanding CRISPR–Cas9 off-target enzymatic reactions
A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity
A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity
Frontiers The Off-Targets of Clustered Regularly Interspaced Short Palindromic Repeats Gene Editing
Engineered CRISPR/Cas9 enzymes improve discrimination by slowing DNA cleavage to allow release of off-target DNA
CRISPR/Cas9 On- and Off-Target Activity Using Correlative Force and Fluorescence Single-Molecule Microscopy
Negative DNA supercoiling induces genome-wide Cas9 off-target activity - ScienceDirect
A quantitative model for the dynamics of target recognition and off-target rejection by the CRISPR-Cas Cascade complex
